Fri Jan 20 2023

55 articles - From Friday Jan 13 2023 to Friday Jan 20 2023

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastrointest Endosc

Best live endoscopy practices: an ASGE white paper.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Hepatology

Outcome of patients with hepatocellular carcinoma and liver dysfunction under Immunotherapy: a systematic review and meta-analysis.

The high heterogeneity across studies reflects the incapacity of the current evidence to support the indication of immunotherapy in HCC patients with relevant liver dysfunction. It is mandatory to report complementary information to Child-Pugh classification such as prior liver decompensation, use of concomitant medication to control ascites, or signs of clinically significant portal hypertension to allow better patient stratification in future studies.

Pubmed   Journal   ReadQx 

Telehealth interventions in patients with chronic liver diseases: a systematic review.

TH interventions in patients with CLD consistently show equivalent or improved clinical outcomes compared to traditional encounters. TH in CLD can bridge the gap in access while maintaining the quality of care for underserved populations.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Impact of malnutrition and nutrition support in hospitalised patients with inflammatory bowel disease.

Malnutrition in hospitalised IBD patients remains an important contributor to readmission, mortality, LOS and healthcare costs. Providing nutrition support to IBD patients may reduce the risk of readmission. Further studies are needed to evaluate the role of nutrition support amongst hospitalised IBD patients to optimise disease and healthcare outcomes.

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Ambulatory pH-Impedance Findings Confirm that Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease.

Grade B esophagitis indicates an objective diagnosis of GERD.

Pubmed   Journal   ReadQx 

Gastroenterology

Anti-integrin avß6 autoantibodies are a novel biomarker that antedate ulcerative colitis.

Finally, high anti-avß6 was associated with a composite of adverse UC-outcomes including hospitalization, disease extension, colectomy, systemic steroid use and/or escalation to biologic therapy in recently diagnosed UC. Anti-integrin avß6 auto-antibodies precede the clinical diagnosis of UC by up to 10 years and are associated with adverse UC-related outcomes.

Pubmed   Journal   ReadQx 

F4/80+Ly6Chigh macrophages lead to cell plasticity and cancer initiation in colitis.

We have identified CD11b + F4/80 + Ly6C high macrophages as key mediators of cancer initiation in colitis-associated cancer. Development of new therapies that target these cells may provide an effective preventative strategy for colitis-associated cancer.

Pubmed   Journal   ReadQx 

Variation in testing for and incidence of celiac autoimmunity in Canada: A population-based study.

Incidence of celiac autoimmunity is high and increasing, despite stable testing rates. Variation in testing patterns may lead to underreporting the incidence of celiac autoimmunity in non-metropolitan areas and more socioeconomically deprived neighbourhoods.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: an analysis of a nationwide multicenter study.

Replacement of thienopyridine with aspirin/cilostazol may be acceptable for minimizing both the risk of post-ESD bleeding and thromboembolism in patients with EGC. In patients on cilostazol monotherapy undergoing ESD, continuation of therapy may be acceptable.

Pubmed   Journal   ReadQx 

Development and validation of a convolutional neural network model for diagnosing Helicobacter pylori infections with endoscopic images - A multicenter study.

This CNN model for diagnosing H. pylori infection showed good overall performance in internal and external validation datasets, particularly in categorizing patients into the never- versus ever-infected groups.

Pubmed   Journal   ReadQx 

SHORT TERM OUTCOMES FOLLOWING POEM, HELLER MYOTOMY AND PNEUMATIC DILATION IN PATIENTS WITH ACHALASIA: A NATIONWIDE ANALYSIS.

In the United States, the risk of readmission and resource utilization is higher in patients with achalasia undergoing PD. The outcomes are comparable between POEM and LHM but there is a significant difference between the utilization of these myotomy procedures.

Pubmed   Journal   ReadQx 

Gut

Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis.

Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the T in AP may help to ameliorate the disease course.

Pubmed   Journal   ReadQx 

Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.

Expression of PNLIP p.T221M in a preclinical mouse model results in CP caused by ER stress and proteotoxicity of misfolded mutant PNLIP.

Pubmed   Journal   ReadQx 

S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.

Altogether, our results uncovered that S100A10 promotes HCC progression significantly via its transfer in EVs and regulating the protein cargoes of EVs. EV-S100A10 may be a potential therapeutic target and biomarker for HCC progression.

Pubmed   Journal   ReadQx 

Hepatology

Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome.

The intestinal virome of MAFLD patients who consume low to moderate amounts of alcohol are significantly different from those who do not, and many features of the intestinal virome of alcohol-consuming MAFLD patients resembles that of AUD patients.

Pubmed   Journal   ReadQx 

Checkpoint inhibitor hepatotoxicity: pathogenesis and management.

Based on the existing literature, we propose evolving management approaches to incorporate strategies to limit excess corticosteroid exposure, and address rare but important presentations of cholestatic hepatitis and fulminant liver failure. Finally, as ICI hepatotoxicity frequently occurs in the context of treatment for advanced malignancy, we review the impact of hepatotoxicity and its treatment on cancer outcomes, and the overall safety of re-challenge with ICI, for patients who may have limited treatment options.

Pubmed   Journal   ReadQx 

Diabetes and cirrhosis: Current concepts on diagnosis and management.

Management is conditioned by whether the patient has either compensated or decompensated cirrhosis. This review gives an update on the complex relationship between cirrhosis and T2DM, with a focus on its diagnosis and treatment, and highlights knowledge gaps and future directions.

Pubmed   Journal   ReadQx 

Environmental eustress promotes liver regeneration via the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice.

The study findings support the brain-liver axis and suggest that environment-induced eustress promotes liver regeneration through the sympathetic nerve/ILC1/IL-22 axis.

Pubmed   Journal   ReadQx 

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the United States.

In the U.S. population, gallstone disease prevalence doubled over 3 decades, possibly due to worsening of metabolic risk factors and growth of laparoscopic cholecystectomy. Gallbladder and biliary tract mortality and gallstone disease associations included factors such as prediabetes or diabetes, liver stiffness and proton pump inhibitors.

Pubmed   Journal   ReadQx 

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression.

Loss of hepatocytes and increased ductular reaction are tightly associated with monocyte-derived macrophage accumulation and represent the most prominent common immunological feature revealing the progression of NAFLD, PSC, PBC and AH, suggesting IBA1 + CD163 low macrophages are key pathogenic drivers of human liver disease progression across diverse etiologies.

Pubmed   Journal   ReadQx 

Mid-line 1 interacting protein 1 promotes cancer metastasis via FOS like 1-mediated matrix metalloproteinase 9 signaling in HCC.

Our study identified MID1IP1 as a regulator in promoting FRA1 mediated-MMP9 signaling and demonstrated its role in HCC metastasis. Targeting MID1IP1-mediated FRA1 pathway may serve as a potential therapeutic strategy against HCC progression.

Pubmed   Journal   ReadQx 

Nicotinamide N-methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.

These data highlight the critical role of NNMT in GBC progression. Inhibition of NNMT by JBSNF-000088 is a potential molecular target for GBC immunotherapy.

Pubmed   Journal   ReadQx 

Outcome of untreated low-level viremia vs. antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis.

Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared to Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research.

Pubmed   Journal   ReadQx 

Portal hypertension and variceal bleeding in patients with liver cancer: Evidence gaps for prevention and management.

Appropriate evaluation and treatment of PHT remain major issues in improving the outcomes of HCC patients. Many questions remain unanswered, opening the field to many areas of research.

Pubmed   Journal   ReadQx 

SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/ ß-catenin signaling.

Collectively, our findings revealed that SERPINA12 is preferentially overexpressed in epithelial HCC CD133+cells and is a key contributor to HCC initiation and progression by driving an AKT/ß-catenin feed-forward loop.

Pubmed   Journal   ReadQx 

Targeting VPS72 inhibits ACTL6A/MYC axis activity in hepatocellular carcinoma progression.

This study reveals the molecular mechanism of ACTL6A/VPS72/MYC in HCC, providing a theoretical basis and therapeutic target for this malignancy.

Pubmed   Journal   ReadQx 

J Hepatol

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models.

Our results identify CD4 T-cell activation during the priming phase as a key determinant for HBV-specific antibody and CD8 T cell immunity using TherVacB as targeted therapeutic vaccine. Impact and implications Therapeutic vaccination is a promising, potentially curative treatment for chronic hepatitis B, but the factors essential to break immune tolerance in HBV carriers and determinants of success remain unclear. Our study provides the first direct evidence that correct priming of HBV-specific CD4 T cells preparing a booster of CD8 T-cell responses determines the success of therapeutic hepatitis B vaccination. Understanding how to fine-tune therapeutic vaccines by the selection of appropriate vaccine components proved essential for its antiviral effect in two preclinical HBV-carrier mouse models and may help to guide the clinical development of therapeutic vaccines for chronic hepatitis B.

Pubmed   Journal   ReadQx 

Neurogastroenterol Motil

Impact of Rome IV criteria on the prevalence of post-infection irritable bowel syndrome.

Rome IV criteria resulted in a 19% lower prevalence of PI-IBS than earlier reported Rome III-based prevalence in a similar population. Rome IV defined PI-IBS patients have greater symptom severity but similar distribution of IBS subtypes.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: bacterial gut symbionts as live biotherapeutic agents in irritable bowel syndrome-a rosy future despite potential long-term safety concerns.

Pubmed   Journal   ReadQx 

Editorial: predictors of disease activity during pregnancy in women with inflammatory bowel disease-a Danish cohort study.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Precision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity?

Pubmed   Journal   ReadQx 

Gastroenterology

ARTIFICIAL INTELLIGENCE-AIDED COLONOSCOPY FOR CHARACTERIZING AND DETECTING COLORECTAL POLYPS: REQUIRED, NICE-TO-HAVE, OR OVER-HYPED?

Pubmed   Journal   ReadQx 

J Hepatol

Novel oncometabolites and metabolic checkpoints involved in hepatocellular carcinoma development.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Esophageal Bulla in Epidermolysis Bullosa.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

AGA Institute Quality Indicator Development and Uses.

Pubmed   Journal   ReadQx 

Net Remission Rates with Biologic and Small Molecule Treatment in Ulcerative Colitis: A Reappraisal of the Clinical Trial Data.

Pubmed   Journal   ReadQx 

Quantifying the Negative Impact of Fast-food Consumption on Liver Steatosis Among United States Adults with Diabetes and Obesity.

Pubmed   Journal   ReadQx 

Tenofovir Alafenamide for Multiple Drug-Resistant Chronic Hepatitis B: A 3-Year Clinical Trial.

Pubmed   Journal   ReadQx 

Therapeutic Drug Monitoring Can Guide the Intravenous-to-Subcutaneous Switch of Infliximab and Vedolizumab: A Simulation Study.

Pubmed   Journal   ReadQx 

Endoscopy

Artificial intelligence in endoscopic assessment of ulcerative colitis: virtual painting with PICaSSO.

Pubmed   Journal   ReadQx 

Pathologic sm2 carries a moderate risk of metastases even without other unfavorable factors, but positive horizontal margins have low local recurrence risk after en bloc resection.

Pubmed   Journal   ReadQx 

Wide-area transepithelial sampling of Barrett's epithelium: "WATS" the benefit?

Pubmed   Journal   ReadQx 

Gastroenterology

Trypsin activity in secretagogue-induced murine pancreatitis is solely elicited by cathepsin B and does not mediate key pathologic responses.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Mediastinal Castleman Disease Diagnosed by Transesophageal Submucosal Tunneling Endoscopic Resection.

Pubmed   Journal   ReadQx 

Hepatology

Introducing Norah Terrault, MD, MPH, Our 2023 AASLD President.

Pubmed   Journal   ReadQx 

March 2023 Hepatology Highlights.

Pubmed   Journal   ReadQx 

Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: bacterial gut symbionts as live biotherapeutic agents in IBS-a rosy future despite potential long-term safety concerns. Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: predictors of disease activity during pregnancy in women with inflammatory bowel disease - a Danish cohort study. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: chronic HDV infection-Is ignorance bliss?

Pubmed   Journal   ReadQx 

Letter: chronic HDV infection-is ignorance bliss? Authors' reply.

Pubmed   Journal   ReadQx 

Letter: ozanimod and latent tuberculosis-authors' reply.

Pubmed   Journal   ReadQx 

Letter: Ozanimod and latent tuberculosis.

Pubmed   Journal   ReadQx 

Letter: rising incidence and poor survival in patients with non-viral HCC - better HCC surveillance and treatment for alcohol-associated and non-alcohol fatty liver diseases are needed. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: rising incidence and poor survival in patients with nonviral HCC-better HCC surveillance and treatment for alcohol-associated and non-alcohol fatty liver diseases are needed.

Pubmed   Journal   ReadQx