55 articles - From Friday Jan 13 2023 to Friday Jan 20 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Hepatology |
Outcome of patients with hepatocellular carcinoma and liver dysfunction under Immunotherapy: a systematic review and meta-analysis. The high heterogeneity across studies reflects the incapacity of the current evidence to support the indication of immunotherapy in HCC patients with relevant liver dysfunction. It is mandatory to report complementary information to Child-Pugh classification such as prior liver decompensation, use of concomitant medication to control ascites, or signs of clinically significant portal hypertension to allow better patient stratification in future studies. |
Telehealth interventions in patients with chronic liver diseases: a systematic review. TH interventions in patients with CLD consistently show equivalent or improved clinical outcomes compared to traditional encounters. TH in CLD can bridge the gap in access while maintaining the quality of care for underserved populations. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Impact of malnutrition and nutrition support in hospitalised patients with inflammatory bowel disease. Malnutrition in hospitalised IBD patients remains an important contributor to readmission, mortality, LOS and healthcare costs. Providing nutrition support to IBD patients may reduce the risk of readmission. Further studies are needed to evaluate the role of nutrition support amongst hospitalised IBD patients to optimise disease and healthcare outcomes. |
| Am J Gastroenterol |
| Gastroenterology |
Anti-integrin avß6 autoantibodies are a novel biomarker that antedate ulcerative colitis. Finally, high anti-avß6 was associated with a composite of adverse UC-outcomes including hospitalization, disease extension, colectomy, systemic steroid use and/or escalation to biologic therapy in recently diagnosed UC. Anti-integrin avß6 auto-antibodies precede the clinical diagnosis of UC by up to 10 years and are associated with adverse UC-related outcomes. |
F4/80+Ly6Chigh macrophages lead to cell plasticity and cancer initiation in colitis. We have identified CD11b + F4/80 + Ly6C high macrophages as key mediators of cancer initiation in colitis-associated cancer. Development of new therapies that target these cells may provide an effective preventative strategy for colitis-associated cancer. |
Variation in testing for and incidence of celiac autoimmunity in Canada: A population-based study. Incidence of celiac autoimmunity is high and increasing, despite stable testing rates. Variation in testing patterns may lead to underreporting the incidence of celiac autoimmunity in non-metropolitan areas and more socioeconomically deprived neighbourhoods. |
| Gastrointest Endosc |
Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: an analysis of a nationwide multicenter study. Replacement of thienopyridine with aspirin/cilostazol may be acceptable for minimizing both the risk of post-ESD bleeding and thromboembolism in patients with EGC. In patients on cilostazol monotherapy undergoing ESD, continuation of therapy may be acceptable. |
Development and validation of a convolutional neural network model for diagnosing Helicobacter pylori infections with endoscopic images - A multicenter study. This CNN model for diagnosing H. pylori infection showed good overall performance in internal and external validation datasets, particularly in categorizing patients into the never- versus ever-infected groups. |
SHORT TERM OUTCOMES FOLLOWING POEM, HELLER MYOTOMY AND PNEUMATIC DILATION IN PATIENTS WITH ACHALASIA: A NATIONWIDE ANALYSIS. In the United States, the risk of readmission and resource utilization is higher in patients with achalasia undergoing PD. The outcomes are comparable between POEM and LHM but there is a significant difference between the utilization of these myotomy procedures. |
| Gut |
Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis. Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the T in AP may help to ameliorate the disease course. |
S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos. Altogether, our results uncovered that S100A10 promotes HCC progression significantly via its transfer in EVs and regulating the protein cargoes of EVs. EV-S100A10 may be a potential therapeutic target and biomarker for HCC progression. |
| Hepatology |
Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome. The intestinal virome of MAFLD patients who consume low to moderate amounts of alcohol are significantly different from those who do not, and many features of the intestinal virome of alcohol-consuming MAFLD patients resembles that of AUD patients. |
Checkpoint inhibitor hepatotoxicity: pathogenesis and management. Based on the existing literature, we propose evolving management approaches to incorporate strategies to limit excess corticosteroid exposure, and address rare but important presentations of cholestatic hepatitis and fulminant liver failure. Finally, as ICI hepatotoxicity frequently occurs in the context of treatment for advanced malignancy, we review the impact of hepatotoxicity and its treatment on cancer outcomes, and the overall safety of re-challenge with ICI, for patients who may have limited treatment options. |
Diabetes and cirrhosis: Current concepts on diagnosis and management. Management is conditioned by whether the patient has either compensated or decompensated cirrhosis. This review gives an update on the complex relationship between cirrhosis and T2DM, with a focus on its diagnosis and treatment, and highlights knowledge gaps and future directions. |
Environmental eustress promotes liver regeneration via the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice. The study findings support the brain-liver axis and suggest that environment-induced eustress promotes liver regeneration through the sympathetic nerve/ILC1/IL-22 axis. |
Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the United States. In the U.S. population, gallstone disease prevalence doubled over 3 decades, possibly due to worsening of metabolic risk factors and growth of laparoscopic cholecystectomy. Gallbladder and biliary tract mortality and gallstone disease associations included factors such as prediabetes or diabetes, liver stiffness and proton pump inhibitors. |
Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression. Loss of hepatocytes and increased ductular reaction are tightly associated with monocyte-derived macrophage accumulation and represent the most prominent common immunological feature revealing the progression of NAFLD, PSC, PBC and AH, suggesting IBA1 + CD163 low macrophages are key pathogenic drivers of human liver disease progression across diverse etiologies. |
Mid-line 1 interacting protein 1 promotes cancer metastasis via FOS like 1-mediated matrix metalloproteinase 9 signaling in HCC. Our study identified MID1IP1 as a regulator in promoting FRA1 mediated-MMP9 signaling and demonstrated its role in HCC metastasis. Targeting MID1IP1-mediated FRA1 pathway may serve as a potential therapeutic strategy against HCC progression. |
Nicotinamide N-methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma. These data highlight the critical role of NNMT in GBC progression. Inhibition of NNMT by JBSNF-000088 is a potential molecular target for GBC immunotherapy. |
Outcome of untreated low-level viremia vs. antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis. Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared to Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research. |
Portal hypertension and variceal bleeding in patients with liver cancer: Evidence gaps for prevention and management. Appropriate evaluation and treatment of PHT remain major issues in improving the outcomes of HCC patients. Many questions remain unanswered, opening the field to many areas of research. |
SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/ ß-catenin signaling. Collectively, our findings revealed that SERPINA12 is preferentially overexpressed in epithelial HCC CD133+cells and is a key contributor to HCC initiation and progression by driving an AKT/ß-catenin feed-forward loop. |
| J Hepatol |
Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models. Our results identify CD4 T-cell activation during the priming phase as a key determinant for HBV-specific antibody and CD8 T cell immunity using TherVacB as targeted therapeutic vaccine. Impact and implications Therapeutic vaccination is a promising, potentially curative treatment for chronic hepatitis B, but the factors essential to break immune tolerance in HBV carriers and determinants of success remain unclear. Our study provides the first direct evidence that correct priming of HBV-specific CD4 T cells preparing a booster of CD8 T-cell responses determines the success of therapeutic hepatitis B vaccination. Understanding how to fine-tune therapeutic vaccines by the selection of appropriate vaccine components proved essential for its antiviral effect in two preclinical HBV-carrier mouse models and may help to guide the clinical development of therapeutic vaccines for chronic hepatitis B. |
| Neurogastroenterol Motil |
Impact of Rome IV criteria on the prevalence of post-infection irritable bowel syndrome. Rome IV criteria resulted in a 19% lower prevalence of PI-IBS than earlier reported Rome III-based prevalence in a similar population. Rome IV defined PI-IBS patients have greater symptom severity but similar distribution of IBS subtypes. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |